Here we describe the design, synthesis and evaluation of the first solid-phase substrates for prolyl oligopeptidase (POP), a cytosolic serine peptidase associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders.This study seeks to contribute to the future design of a one-bead one-compound (OBOC) peptide library
Bacterial Kidney Disease, caused by Renibacterium salmoninarum (Rs), is widespread and can cause significant mortality at most life stages in infected salmonids.Rs is commonly found Tomatoes in inland trout, which can be carriers of the bacterium.Lethal spawns can be used to control vertical transmission to progeny through the culling of eggs from
Industrial portal frames near to other buildings must keep their vertical walls standing in fire in order to prevent fire spread.A recently developed analysis, implemented in the program Vulcan, using a combination of static and dynamic solvers, has shown that the strong base connections recommended by Feminine Care the current design method may no